The Mulhuddart boxer was defeated by Romanian Lacramioara Perijoc on a unanimous decision in Sofia, Bulgaria, in their last 16 contest.
After a close first round, the Eastern European boxer would pull away for a deserved win against the big-punching Irishwoman.
Head coach Zaur Antia relayed that Duffy gave it everything against a tough and experienced opponent.
It was an inauspicious start for Ireland at the tournament, but they will aim to the get back to winning ways tomorrow when there are two fighters in action – Lauren Hogan and Gráinne Walsh.
European Women’s Championships Sofia, Bulgaria
(Last 16 bouts unless stated)
54kg Dervla Duffy (Ireland) lost to Lacramiora Perijoc (Romania) 0-3
48kg Lauren Hogan (Ireland) v Katerina Pinigiana (Russia)
69kg Grainne Walsh (Ireland) v Marija Petovic (Serbia)
60kg Shauna O’Keeffe (Ireland) v Aneta Rygielska (Poland)
57kg Moira McElliggot (Ireland) v Sara Beram (Croatia)
64kg Kellie Harrington (Ireland) v Aleksandra Ordina (Russia) or Lina Skoghgen (Sweden)
75kg Christina Desmond (Ireland) v Oksana Trofimova (Russia)
48kg Lauren Hogan (St.Brigid’s Edenderry)
54kg Dervla Duffy (Mulhuddart)
57kg Moira McElliggot (St Michael’s Athy)
60kg Shauna O’Keeffe (Clonmel)
64kg Kellie Harrington (Glasnevin)
69kg Grainne Walsh (Sparticus)
75kg Christina Desmond (Fr Horgans)
Team manager: Noreen Glendening
Physio: Caoimhe Gilmore
Coaches: Zaur Antia, Eddie Bolger, Dmitri Dimitruc
R&J: Sadie Duffy