The Belfast feather took on Mexican Luis Lugo in the headline fight at the Titanic Exhibition Centre in what was a back-and-forth battle.
The popular Shankill man was hurt at the end of the second before bouncing back and flooring Lugo in the fourth with a body shot. The Mexican would retire at the end of the round following a sustained barrage from McCullough which led to an arm injury.
The win saw McCullough move to 16(10)-3(2) and claim the WBO Inter-Continental title along with a place in the organisation’s rankings.
Watch Marco McCullough v Luis Lugo in full below:
Video courtesy of Davey Boy Essex UK